This is an interesting study. Sadly I have lost 2 Rotties to this disease. It does not matter if the dog is neutered/spayed or not...it seems to hit them in middle age or older.
Dog breeds and body conformations with predisposition to osteosarcoma in the UK: a case-control study
Background Osteosarcoma is an aggressive and painful bone neoplasm in dogs. Previous studies have reported epidemiological associations suggesting that large body mass, long bone length and the genetics of certain breeds including the Rottweiler are associated with elevated osteosarcoma risk...